Antimicrobial Susceptibility Testing Protocols Pdf Download
bd40bc7c7a Accepted July 27, 2009. Allowing a website to create a cookie does not give that or any other site access to the rest of your computer, and only the site that created the cookie can read it.. There is a need for development of new automated instruments that could provide faster results and also save money by virtue of lower reagent costs and reduced labor requirements. The CLSI zone size and MIC interpretive criteria are established by analysis of 3 kinds of data: (1.) microbiologic data, including a comparison of MICs and zone sizes on a large number of bacterial strains, including those with known mechanisms of resistance that have been defined either phenotypically or genotypically; (2) pharmacokinetic and pharmacodynamic data; and (3) clinical studies results (including comparisons of MIC and zone diameter with microbiological eradication and clinical efficacy) obtained during studies prior to FDA approval and marketing of an antibiotic . J Clin Microbiol 2003;41:3627-30.
Two studies [17, 18] have shown that providing rapid susceptibility test results can lead to more timely changes to appropriate antimicrobial therapy, substantial direct cost savings attributable to ordering of fewer additional laboratory tests, performance of fewer invasive procedures, and a shortened length of stay. 23 Comments books-Nelson Textbook of Pediatrics 19th(pdf) 18 Comments Copyright Am-Medicine.com 2016. ISO 20776-2. The direct detection of resistance genes by polymerase chain reaction or similar techniques has limited utility, because only a few resistance genes are firmly associated with phenotypic resistance (eg, mecA, vanA, and vanB ) . Vancomycin MICs with methicillin-resistant Staphylococcus aureus (MRSA) isolates differ based upon the susceptibility test method used. A recent, international standard on susceptibility test device evaluation proposes similar but not identical criteria for acceptable accuracy . disclose their membership on microbiology advisory committees for BD Diagnostics and bioMrieux. Generally, reporting of a category result of susceptible, intermediate, or resistant provides the clinician with the information necessary to select appropriate therapy. There are 4 automated instruments presently cleared by the FDA for use in the United States.